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Keng-Hui Lin's Lab

We are an interdisciplinary research group with members of diverse scientific backgrounds, including physics, biology, chemistry, and engineering. We are curious about how physical factors affect cell behaviors, and how cells utilize physical force to perform biological functions. The study of how cells sense and respond to the physical microenvironment is mechanobiology. In the past, most of studies are carried out on two-dimensional (2D) substrates. My lab focuses on three-dimensional behaviors, which are good for testing current understanding based on 2D systems. Our biological research addresses how the 3D microenvironment affects cellular shapes and functions, with the ultimate goals of understanding cell morphodynamics and tissue morphogenesis and applying this knowledge to regenerative medicine and drug screening. In addition to investigating 3D mechanobiology, we also study mechanobiology in vivo, particularly, on zebrafish, which is a fascinating model system. Our approaches exploit knowledge and techniques from soft matter physics such as advanced optical microscopy, image analysis, and fluorescent probes for visualizing microscopic details.

News

Members

林耿慧

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PI
khlin@phys.sinica.edu.tw
kenghui@gate.sinica.edu.tw
(02) 27896763
Ph. D., Physics and Astronomy, University of Pennsylvania.

Marco P. de Leon

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PhD in Biotechnology
Molecule and Biological Agricautural Science
Taiwan International Graduate Program Academia Sinica-National Chung-Hsing University
Msc in Biochemistry University of the Philippines Manila
BSc in Chemistry Polytechnic University of the Philippines
Sep. 2016 - current

劉又萱

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Research Assistant
Sept. 2020 - Current
c54054029@gs.ncku.edu.tw
B.S. Life sciences and Biomedical Engineering double major, National Cheng Kung University

林治

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NTU chemistry undergrad
Oct. 2021 - Current

Karen G. Rosal

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postdoc, Aug. 2022- Current
Karen G. Rosal is a postdoctoral research fellow. She finished her PhD in Molecular and Cell Biology under the TIGP-MCB program. She earned her masters degree at Okayama University Graduate School of Life Sciences and bachelors degree in Biology at the University of the Philippines
Los Baños.

羅尉彰

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Wei-Chang completed his PhD at the University of Warwick, UK. He then worked as a postdoctoral researcher on a number of topics in biological physics, including modelling bacterial swarms and the dorsal closure of Drosophila. He currently studies mechanobiology by using zebrafish as the model organism.
Postdoctoral Research Fellow, Oct. 2022 - Current

謝映竹

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Research Assistant, Oct. 2022 - Current
sieyingjhu@gmail.com
M.S. Chemistry, National Taiwan University
B.S. Chemistry, National Tsing Hua University

鄭愷修

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r09245015@ntu.edu.tw
Jan. 2023 - Current
NTU Physics Graduate Student

Yi-Fang Lo

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NTU physics undergrad, June 2023-Current

蘇昱融

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B.S. Physics, Goettingen University.
M.S. Physics, Goettingen University.
Hello I love cats, drawing and design. Nice to meet ya!

Research Assistant, July. 2023 - Current

吳家馨

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Ph.D. Student, Sept. 2023 - Current

Selected Research Projects

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Monodisperse liquid foam is generated by a microfluidic device self-assembled into crystalline order.
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Comparison of cells in spherical pores (top).
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Reconstructed image of a cyst with nuclei.
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Measuring traction force.
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Solid foam, also known as "cellular solid", which is an important class of engineering materials consists of an assembly of cells with solid edges or faces that are packed together to fill space.

Publications

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Openings: we are eager of new fresh chickens

The availability of positions in our group varies with time. Please contact Dr. Lin directly with the required materials (listed below) if you are interested in joining the group.

We welcome people who share our passion and fascination for soft matter physics and integrated physical biology. We recruit from a wide range of backgrounds in physics, chemistry, biology, material science, bioengineering, applied mathematics, and computer science, as well as mechanical, chemical, electrical, and related engineering fields. Research projects often require training in more than one field. Candidates must possess some of the following and be motivated to:
  1. Engate in independent and critical thinking
  2. Acquire good teaching and presentation skills
  3. Develop experience with quantitative analysis
  4. Enjoy collaborating with colleagues
  5. Embrace new challenges
  6. Be open-minded and not take criticism personally.
English proficiency is required for all positions. Although it is not necessary to submit standardized test scores, you must demonstrate the ability to present and discuss research in English with no difficulties.

Visiting Scientists

We welcome experienced researchers to exchange ideas and work with us. Some funding may be provided for visitors. For domestic scientists, you can apply for the short term visiting program sponsored by Academia Sinica.




Postdoctoral Researchers
Postdocs with solid academic performance and graduate research experiences are always encouraged to apply. At this moment, we are interested in candidates with backgrounds in optical imaging, mechanical engineering, soft matter physics, and strong coding and analytical skills.
Interested candidates should send a cover letter defining your interests, your research achievement, and your reasons to work in our group. Please also send a recent CV and a list of references or request that three recommendation letters be sent separately.
Postdoc candidates are encouraged to apply to the following fellowships
  1. Postdoc fellowship program in Academia Sinica
  2. NSF International Fellowship Program for US citizens or permanent residents




PhD Thesis Students

If you are interested in carrying out your thesis research in the Lin lab, please appl to the pertinent graduate programs such as Dept. of Physics and Institute of Biophysics at National Central University, Institute of Genome Biology and Systems at National Taiwan University, NANO and CBMB program of Taiwan International Graduate Program (TIGP) at Academia Sinica. Candidates in other PhD programs who wish to work in my lab must contact Dr. Lin directly.
Interested candidates should send a cover letter that describes your research experiences, CV, undergrad/master transcripts, and your publication records (or thesis).




Master Thesis Students

The most straightforward way is to complete a master's thesis with the Lin lab is to be a studentat at the Institute of Physics/Biophysics at National Central University. In the past, I have supervised students from various institutes, including NTU physics/applied physics, chemical engineering, mechanical engineering, and applied mechanics; NYMU immunology and microbiology, and biophotonics; NTHU physics, and material sciences.
Interested candidates should send me a CV, undergrad transcript, and a cover letter which explains why you are interested to conduct your master thesis in my lab and your plan after graduation.




Full-time Research Assistants

The training and criteria for research assistants are the same as those for PhD students. Candidates must exhibit a strong commitment to research and demonstrate a solid background in academic performance. People who can commit for more than two years are considered at high priority. The time spent in the lab can be applied toward a PhD if you decide to pursue a PhD in the lab. People with undergraduate degrees who plan to apply for graduate programs abroad within a year will not be offered full salary for the full year.
Interested candidates should send Dr. Lin a CV, reference contact information, undergrad/master transcript, master's thesis, and a cover letter that describes your goals for working in the Lin lab and how you anticipate that your experience in the Lin lab will further your career.




Part-time Undergraduate Research Assistant

These positions are for undergraduates who wish to gain research experience during their undergraduate years. Candidates must exhibit a strong commitment to research by coming to the lab for a fixed amount of time every week for at least a year.
Please send Dr. Lin your transcript and a cover letter describing your personal goals, your plan after graduation, and your expectation to work in the Lin's lab.




Summer Interns

Various internship opportunities are available but only highly motivated candidates with outstanding academic backgrounds will be considered. Please send Dr. Lin your transcript, and a cover letter describing your personal goals and your expectations for working in the Lin's lab over the summer.
Applicants can also apply for one of the following internship programs.
  1. TIGP International Internship This fellowship is particularly important for international students who are considering pursuing their PhD research in the Lin lab.
  2. NSF Summer Institutes and NSF International Research Experiences for Students (IRES)
  3. NPAS Summer Internship for Undergrads
  4. AS IOP Summer Internship for Undergrads
  5. Taiwan Tech Track Programs








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Extra Spicy

Forbidden Links


Spicy Training courses
  • The Center for Biotechnology at National Taiwan University offers many training courses on the latest biotechnologies. We especially recommend the BCT course which helps many lab members to acquire biotechnique.
  • The Bioresource Collection and Research Centerat the Food Industry Research and Development Institute annually offers training courses in Tissue Cell Culture and Stem Cell Culture.
  • at the Marine Biological Laboratory. This course is for people who are interested to work at the interface between physical sciences and biology.

Useful Spicy Websites









Direction:

Our lab is located at the third floor of Old Building of Institute of Physics. Once you got to Institute of Physics, you can ask the front desk and change your ID there. Lin's office is right cross from the elevator.

Location of Institute of Physics in Academia Sinica

http://www.sinica.edu.tw/as/map/asmap.html

We are at the Building 33.

Directions to Academia Sinica (in Taipei)

1. By Bus :

205, 212, 212-Straight Line, 270, 270(Shuttle), 276, 306, 306(Shuttle), 620, 645, 645(Extended), S1, S12, S12(Shuttle), S5, BL25, get off at Academia Sinica stop.

2. By MRT :

a. Take Blue Line (Banqiao-Nangang Line) to Nangang Exhibition Hall (the last stop). Get out from Exit No. 5, cross the street for bus 306 and get off at Academia Sinica Stop.
b. Take Blue Line (Banqiao-Nangang Line) to Kunyang Station; Get out from Exit No 4, cross the street for bus 212-Straight Line, 270, 270(Shuttle), BL25, get off at Academia Sinica Stop.

From Airport to Academia Sinica

1. Taxi Services

Taking a taxi from the airport to Academia Sinica takes 40 minutes but is more costly. (Depending on meters, around NT$ 1,500)

2. Airport Bus

Airport bus ticket counters are located at the Arrival Passenger Reception area. Tickets usually cost between NTD$ 125 and 150, depending on the bus company. These buses are available every 20 minutes. At Terminal I, Bus Platform is on the southwest side of the Arrival Passenger Reception Area and the Terminal II Bus Platform is on the northeast side of the Arrival Passenger Reception Area on the first floor of the terminal.